霍亂毒素B亞基抗體（cat#703）

Anti-Cholera Toxin B Subunit (Goat)

產(chǎn)品組成：
用100ul水重懸后，為含100ul抗霍亂毒素B亞基的山羊抗血清，加入了0.1%的NaN3用作抗體保護(hù)劑。
實(shí)驗(yàn)：
用該產(chǎn)品（依據(jù)批次而定）針對(duì)0.5mg/ml的霍亂毒素B亞基形成免疫沉淀?xiàng)l帶的最大稀釋度為：1:4。
產(chǎn)品保存：
無(wú)菌凍干粉，重懸前2-8℃保存。
防護(hù)：
操作時(shí)，請(qǐng)穿上實(shí)驗(yàn)服，帶上手套和防護(hù)眼鏡。此產(chǎn)品僅供科研應(yīng)用，不可用于診斷試劑。

Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. The cholera toxin is an oligomeric complex made up of six protein subunits: a single copy of the A subunit (part A, enzymatic), and five copies of the B subunit (part B, receptor binding), denoted as AB5. Subunit B binds while subunit A activates the G protein which activates adenylate cyclase. The five B subunits - each weighing 11 kDa, form a five-membered ring. The A subunit which is 28 kDa, has two important segments. The A1 portion of the chain (CTA1) is a globular enzyme payload that ADP-ribosylates G proteins, while the A2 chain (CTA2) forms an extended alpha helix which sits snugly in the central pore of the B subunit ring. This structure is similar in shape, mechanism, and sequence to the heat-labile enterotoxin secreted by some strains of the Escherichia coli bacterium.